Psyllium fiber improves hangovers and inflammatory liver injury by inhibiting intestinal drinking

Psyllium fiber improves hangovers and inflammatory liver injury by inhibiting intestinal drinking

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Introduction: Excessive alcohol intake often results in hangovers and inflammatory liver damage, posing a significant health concern.Current treatment options for hangovers are still insufficient, highlighting the urgent need for new therapeutic approaches.Psyllium fiber (PF) is well-known for its gastrointestinal benefits, but its effect on Dish Brushes hangovers is less explored.Methods: We utilized a mouse model with a single binge drinking (4 g/kg) to induce hangover and inflammatory liver injury.

Intestine and liver injury were serologically and histologically estimated.Hangover symptoms were assessed using cylinder and footprint tests to objectively quantify hangover symptoms in mice.Results: Binge drinking significantly activated alcohol-metabolizing enzymes in the small intestine and liver, leading to inflammatory damage.Concurrently, there was a rise in alcohol metabolites such as acetaldehyde and acetone, which exhibited a positive correlation with hangover symptoms in mice.

Interestingly, the oral administration of PF (100 mg/kg) alongside alcohol consumption significantly reduced the activity of these enzymes and lowered the levels of alcohol metabolites.Mice treated with PF exhibited a considerable improvement in hangover symptoms and a reduction in hepatic inflammation, compared to control groups.Furthermore, in vitro experiments using HepG2 cell lines and semipermeable membranes demonstrated that PF effectively inhibits alcohol absorption into the body.Discussion: In conclusion, PF demonstrates a potential protective effect against alcohol-induced hangover and liver injury by inhibiting the absorption of alcohol and lowering hangover-related alcohol metabolites.

This study Beads suggests that PF could serve as an effective therapeutic option for mitigating the adverse effects of excessive alcohol consumption.